t-cell acute lymphoblastic leukemia with del (7) (q11.2q22) and aberrant expression of myeloid markers.

نویسندگان

ahmad ahmadzadeh cancer, petroleum and environmental pollutants research center, ahvaz jundishapur university of medical sciences, ahvaz, iran.

sajedeh saedi research center of thalassemia & hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran.

kaveh jaseb research center of thalassemia & hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran.

ali amin asnafi research center of thalassemia & hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran.

چکیده

t cell acute lymphoblastic leukemia (all) is an invasive disease with a higher incidence in children and adolescents. in terms of immunophenotype, t-all is positive for cd2, cd7, cd34 and hla-dr, and the level of these markers is increased with increasing age. in addition, the myeloid markers (cd13, cd33) are sometimes expressed in t-all. in this study, we introduce a rare case of a 28-year-old woman with t-all with aberrant expression of myeloid markers (cd13), without lymphadenopathy and with 94% blasts in bone marrow specimens. the patient has the rare karyotype of 46,xx del(7)(q11.2q22). the presence of del7 is a rare phenomenon in t-all.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

T-cell Acute Lymphoblastic Leukemia with del (7) (q11.2q22) and Aberrant Expression of Myeloid Markers

T cell acute lymphoblastic leukemia (ALL) is an invasive disease with a higher incidence in children and adolescents. In terms of Immunophenotype, T-ALL is positive for CD2, CD7, CD34 and HLA-DR, and the level of these markers is increased with increasing age. In addition, the myeloid markers (CD13, CD33) are sometimes expressed in T-ALL. In this study, we introduce a rare case of a 28-year-old...

متن کامل

PROGNOSTIC VALUE OF MYELOID ANTIGEN EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA

Expression of cell surface molecules associated with lymphoid and myeloid lineage differentiation on the blasts of 53 patients with acute lymphoblastic leukemia (ALL) was investigated. 1.9% of cases were only HLA"7DR+ 7.6% were HLA-DR+, CDI9+ 22.6% were HLA-DR+, CDI9+, CDI0+ 30.2% were HLADR+, CDI9+, CDlO±, CD20+ and 37.7% were HLA-DR±, CD7+, CD5±. Aberrant expression of one or more myeloi...

متن کامل

Translocation t(8;22) and monosomy 7 in a case of acute lymphoblastic leukemia expressing myeloid markers.

The simultaneous coexpression of lymphoid and myeloid markers has been observed in some cases of childhood acute lymphoblastic leukemias (ALL). In this paper, we describe a 6-year-old male patient with an ALL expressing myeloid antigens in whom a novel karyotypic association, t(8;22) and monosomy 7, and high Ag-NOR activity were found concomitantly with a very short survival.

متن کامل

Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia

Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...

متن کامل

Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomi...

متن کامل

Myeloid/T-cell acute lymphoblastic leukemia in children and adults

Until recently, few molecular aberrations were recognized in T-cell acute lymphoblastic leukemia (T-ALL) and they were restricted to aberrations involving the T-cell receptor (TCR). The introduction of powerful technologies has allowed to identify novel rearrangements. In this context, we have performed a gene expression profiling analysis on a relatively large cohort (n=69) of adult patients w...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of hematology-oncology and stem cell research

جلد ۷، شماره ۴، صفحات ۴۰-۴۴

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023